Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. If you and your doctor determine that Fasenra is safe and effective for you, youll likely take it long term. MNT is the registered trade mark of Healthline Media. Check with your doctor immediately if any of the following side effects occur while taking benralizumab: Some side effects of benralizumab may occur that usually do not need medical attention. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Ask your healthcare professional how you should dispose of any medicine you do not use. But alcohol may trigger asthma attacks for some people. Children younger than 12 years of ageUse and dose must be determined by your doctor. The risks vs benefits need to be weighed up. Common and Rare Side Effects for Fasenra Syringe - WebMD There are no known pharmacokinetic drug interactions with Fasenra. Common side effects of Fasenra include: headache, sore throat, fever, hypersensitivity reactions, and injection site reactions (pain, redness, itching, or a small lump) Dosage for Fasenra? In comparison, 3% of people who took a placebo (treatment with no active drug) had an allergic reaction. Fasenra contains the active drug benralizumab, while Nucala contains the active drug mepolizumab. But you should tell your doctor if these side effects become more severe or dont go away. Fasenra is indicated to treat severe eosinophilic asthma. Fasenra belongs to a class of drugs called interleukin-5 monoclonal antibodies. When administered subcutaneously to patients with asthma, Fasenra has a bioavailability of 59%. Is the ketogenic diet right for autoimmune conditions? Heres some information about the uses of Fasenra and Xolair. Each syringe or pen contains one dose of Fasenra. Insulin resistance. It may also be called a monoclonal antibody. So you shouldnt use it to treat asthma flare-ups or a severe kind of asthma called status asthmaticus. Tell your doctor immediately if you become pregnant while being administered Fasenra and enroll in the Pregnancy Exposure Registry by calling 1-877-311-8972 or by visiting mothertobaby.org/Fasenra. The dose of this medicine will be different for different patients. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Heres a short list of some of the mild side effects that Fasenra can cause. But if your throat pain is severe or lasts more than a few days, tell your doctor. Muscle weakness. If you would like to report to the FDA a side effect youve had with Fasenra, you can do so through MedWatch. Common side effects include headache, fever, pharyngitis, and injection site reactions. Keep this container away from children and pets. Gastrointestinal problems. The dissociation constant of this binding is 11 pM. Its not known whether Fasenra is safe to take while pregnant. What should I know about Fasenra vs. Nucala? Medically reviewed by Carmen Pope, BPharm. In clinical trials, people who took the drug for up to 48 weeks did not experience any long-term side effects. The starting dose for Fasenra is one injection every 4 weeks for the first 12 weeks. There may be a small drop of blood at the injection site but this is normal. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). If your dose is different, do not change it unless your doctor tells you to do so. IL-5 is the main cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils. Dupixent (Dupilumab): Side Effects, Cost, and More - Healthline Fasenra: Side effects, dosage, for asthma, and more - Medical News Today Fasenra should be kept inside its original package and protected from light. Does Fasenra have side effects? However, anecdotally, some people have reported a small amount of weight gain on blog sites, although equally as many people report weight loss as well, usually because they no longer need to take as much prednisone. These medications may interact and cause very harmful effects. Two clinical studies looked at 2,510 people with severe eosinophilic asthma. . You might also be interested in how Fasenra compares with Dupixent. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. The Food and Drug Administration (FDA) approves prescription drugs such as Fasenra to treat certain conditions. Sharing this information can help you avoid potential interactions. To learn more about this side effect, see Allergic reaction just below. Use each Fasenra Pen only one time. Tell other health professionals that you are being administered Fasenra. Fasenra Side Effects: Common, Severe, Long Term - Drugs.com Before your appointment, write down questions such as: How will Fasenra affect my body, mood, or lifestyle? Your doctor will likely have you continue to use inhaled or oral corticosteroids. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The condition is caused by the breakdown of the cartilage that cushions the joints, allowing the bones to rub against each other. Theyre both given as an injection under the skin. All rights reserved. Fasenra belongs to the class of medicines known as interleukin inhibitors. Off-label use is when a drug thats approved to treat one condition is prescribed to treat a different condition. This enhances apoptosis, or programmed cell death, of eosinophils via a process called antibody-dependent cell-mediated cytotoxicity (ADCC). Fasenra comes in two forms: a prefilled syringe and a prefilled autoinjector pen. Fasenra and Nucala belong to the same class of drugs. If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it. Symptoms of an allergic reaction to Fasenra can include: swelling of your face, including your mouth and tongue trouble breathing fainting dizziness low blood pressure or feeling lightheaded. These lists contain examples of more common side effects that can occur with Fasenra, with Nucala, or with both drugs (when taken individually). Its not known whether its safe to take Fasenra while pregnant or breastfeeding. See the Side effect details section above to learn more. People with asthma are more likely to experience sinusitis, and sinusitis can trigger asthma. The number of people who develop asthma and allergies grows yearly. Our phase IV clinical studies alone cannot establish cause-effect relationship. Results from a phase III trial also showed that Fasenra works quickly, improving lung function in as little as 4 weeks. Pain, scratchiness, or irritation in the throat may occur with Fasenra. The expiration date helps guarantee that the medication is effective during this time. But if you think youre having a medical emergency, call 911 or your local emergency number. Since oxygen is carried in air, this condition reduces how much oxygen reaches the cells inside your body. A program called Fasenra 360 may also help lower the cost of the drug. There is no information on the safety of Fasenra during breastfeeding. Fasenra and Nucala both belong to the same class of drugs called anti-interleukin 5 monoclonal antibodies. If you have a headache during your treatment, itll likely go away after a few hours. Fasenra is used to treat severe eosinophilic asthma in adults and in children ages 12 years and older. Flu-like symptoms. Eosinophils are one of multiple types of cells and mediators that are involved in inflammation, and inflammation is an important component in the pathogenesis of asthma and some other conditions. This helps prevent others, including children and pets, from taking the drug by accident. Fasenra will not treat an asthma attack or exacerbations of asthma (acute bronchospasm or status asthmaticus). If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Fasenra is given as an injection under your skin (subcutaneous injection). Fasenra has a linear pharmacokinetic profile. . Ask your doctor what other COPD treatment options are right for you. There are currently no biosimilar forms of either drug available. For this use, the drug is approved in adults as well as children ages 6 years and older. Fasenra and Xolair are both prescribed to treat asthma. But allergic reactions to Fasenra are rare. The amount of medicine that you take depends on the strength of the medicine. Although not all of these side effects may occur, if they do occur they may need medical attention. Do not warm it in any other way. Both forms of the drug have one strength: 30 mg/mL. There arent any known interactions between Fasenra and any drugs, herbs, foods, or supplements. AstraZeneca, the manufacturer of Fasenra, has reimbursement counselors on staff who can discuss cost savings options with you. Store in the refrigerator. Includes common brand names, drug descriptions, warnings, side effects and dosing information. These types of drugs are large proteins that affect the way certain parts of your body work. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. If you suddenly stop using the corticosteroid medication, you may also have withdrawal symptoms (such. Heres some detail on several of the side effects this drug may or may not cause. Fasenra may be used in children ages 12 years and older. Neither drug is a rescue inhaler. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Its not known if Fasenra is safe to take during pregnancy. Keep Fasenra inside its original package and protect the autoinjector pens from light. (An active drug is an ingredient that makes a medication work.) Fasenra is currently approved as an add-on . Its not indicated to treat any other eosinophilic disease, acute bronchospasms, or other asthmatic episodes. Do not freeze. Do not use this medicine if it is cloudy or if there are particles in it. This drug should not be used in certain cases. Some conditions (such as asthma, allergies) may become worse when the drug is suddenly stopped. And they want you to get the best care possible. Its not known for sure if Fasenra is safe to use while youre breastfeeding. This medicine is available only with your doctor's prescription. They were then given Fasenra or a placebo (treatment with no active drug). If not used within that time frame, the product must be discarded. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. Fasenra (benralizumab) [Package insert]. A single copy of these materials may be reprinted for noncommercial personal use only. The medicine should look clear to pale yellow and may contain a few translucent white to off-white particles. These lists dont include all possible side effects. It is also used in patients whose asthma has an eosinophilic phenotype. Joint pain Causes - Mayo Clinic Both Fasenra and Xolair (omalizumab) are biologic medications, which means theyre made from living cells rather than chemicals. This reduces inflammation and is thought to reduce asthma symptoms. Detailed drug Information for Fasenra. They can help make sure that you feel comfortable with your treatment plan. Off-label drug use is when a drug thats approved for one condition is used for a different one thats not approved. These side effects may go away during treatment as your body adjusts to the medicine. It is given to patients whose asthma is not controlled with their current asthma medicines. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Below are some common questions about taking Fasenra. Fasenra can cause mild or serious side effects. No. (For more information, see the What is the Fasenra injection used for? section above.). Rarely, allergic reactions may occur. People who took either Fasenra or Nucala had fewer flare-ups than people who took a placebo (treatment with no active drug). All the people in the studies were also taking at least two other medications to treat their asthma. Fasenra is a prescription medication used to treat severe eosinophilic asthma in adults and some children. Fasenra is given as an injection under the skin. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Other drugs are available that can treat severe eosinophilic asthma. This will help prevent skin problems from the injections. To learn more, see the What is the Fasenra injection used for? section below. In certain people, Nucala is also approved to treat: Each syringe or pen contains one dose of Fasenra. In addition to the use listed above, Fasenra may be used off-label for other conditions. Two clinical studies found that Fasenra was not effective at preventing flare-ups in people with moderate to very severe COPD. Xolair also shouldnt be used to treat other eosinophilic conditions. There have been no formal interaction studies conducted with Fasenra, according to the product information, and no interactions are documented. How long can you stay on Fasenra? - AdvertisingRow.com If you have a certain kind of asthma, your doctor may prescribe Fasenra. Fasenra isnt currently available in biosimilar form. Be sure to take the dosage your doctor prescribes for you. Both biosimilars and generics are considered to be just as safe and effective as their parent drugs. Fasenra attaches to eosinophils by binding to this receptor. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Here we look at how Fasenra and Nucala are alike and different. To learn more about how Fasenra and Dupixent are alike and different, ask your doctor or pharmacist. The Fasenra site also has some useful resources on using the autoinjector pen. Both drugs are also known as monoclonal antibodies. While they can cause similar side effects, different side effects are possible with each drug. These cells cause inflammation (swelling) and trigger asthma flare-ups. But if your fever lasts more than 3 days or is higher than 103F (about 39.4C), tell your doctor. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Fasenra syringes cost significantly more than Xolair syringes. Asthma is called severe when you keep having symptoms despite using multiple asthma treatments. If you are using this medicine at home, your doctor or nurse will teach you or your caregiver how to inject the medicine. If you or your sexual partner can become pregnant, talk with your doctor about your birth control needs while youre using Fasenra. Xolair Side Effects: What They Are and How to Manage Them - Healthline Research has shown approximately 12% of people receiving Fasenra develop antibodies to it, which has been associated with increased clearance of Fasenra and increased blood eosinophil levels. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Fasenra is also called a monoclonal antibody. Fasenra (benralizumab)." In the first study, 35% of people who took Fasenra had asthma flare-ups, compared with 51% of people who took a placebo. (Polyps are tissue growths that can make it difficult to breathe through your nose.) Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Fasenra and Joint pain - a phase IV clinical study of FDA data The drug comes in one strength: 30 milligrams per milliliter (mg/mL). They may recommend treatments to help you feel better. However, its not known if the drug would have any effect on a child who is breastfed. Can Fasenra Cause Joint Pain - dolpxy.com It is created by eHealthMe based on reports of 7,517 people who have side effects when taking Fasenra from the FDA, and is updated regularly. Seek medical advice if your asthma worsens while on Fasenra. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Nasal polyps are growths in the lining of your nose that arent cancerous. Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of Fasenra. Keep Fasenra in the refrigerator at 36F to 46F (2C to 8C) before use. You should refer to the prescribing information for Fasenra for any updates or newly noted interactions. The elimination half-life of Fasenra is approximately 15.5 days. If there is a clear pattern of weight gain, talk with your doctor. After you hear the second click, continue to hold it down for 5 more seconds. Biosimilars are based on biologic medications, which are made from living sources such as proteins or DNA. Its available in two forms: Keep reading for information about Fasenra, including the drugs side effects, uses, and dosage, and more. Widespread body pain. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Factors to consider include those in the list below. Asthma is a condition that affects your airways, making them swollen. Fasenra is approved to treat severe eosinophilic asthma in children ages 12 years and older. Learn how stress can impact your asthma and what you can do to help manage it. Although headaches can be common while using Fasenra, theyre usually not serious. So you shouldnt use it to treat asthma flare-ups or a severe kind of asthma called status asthmaticus.